snpAD: an ancient DNA genotype caller

Accurate DNA Base Caller

Ancient DNA from Human and Animal

Research on ancient DNA (aDNA) has the potential to enable molecular biologists and archeologists to decipher certain aspects of history by direct looking into the past. However, several major problems in this field limit the applicability of aDNA studies, most importantly contamination with modern DNA and postmortem DNA degradation. In this study we extracted and analyzed aDNA obtained from ~3...

Ococo: an online consensus caller

Motivation: The usual approach to variant calling from NGS data consists in inferring single nucleotide variants (SNVs) or more complex differences from read alignments. Consequently, variant calling is performed after all reads have been mapped to a reference genome and all read alignments are available. Existing variant callers usually operate by first sorting the alignments in increasing ord...

Hasanlu IVB: An Ancient DNA Pilot Project

Ancient DNA

Ancient DNA is a field of molecular evolutionary biology that usesDNA sequence data recovered frompoorly preserved organisms, usually deceased for hundreds to hundreds of thousands of years. Ancient DNA data can provide unique snapshots in time to better understand how populations and species evolve. The field was born in the early 1980s,when thefirst ancientDNAsequences were recovered from pre...